• Tutorial
  • Product Matrix
  • Validate
  • Regulatory
  • ROI
  • News
  • Blog
  • Events
  • References
  • LinkedIn Group
  • Training & Consulting
  • Contact

The RMM Blog

Updated routinely by Dr. Michael J. Miller, our RMM blog will keep you informed of new and noteworthy technologies, reviews of recent publications and presentations, upcoming conferences and training events, and what's changing in the RMM world. You can also follow our blog on Twitter, Facebook, LinkedIn and RSS.

Follow us on Twitter Follow us on Facebook LinkedIn RSS Feed

Thursday, April 16, 2015

New Biosensing Platform Could Quickly and Accurately Diagnose Disease and Monitor Treatment Remotely

In much the same way that glucometers and pregnancy tests have revolutionized in-home diagnostic testing, researchers from Florida Atlantic University and collaborators have identified a new biosensing platform that could be used to remotely detect and determine treatment options for HIV, E-coli, Staphylococcus aureas and other bacteria. Using a drop of blood from a fingerprick, this novel biosensing platform provides clinically relevant specificity, sensitivity and detection of pathogens from whole blood and plasma.

The thin, lightweight and flexible materials developed by these researchers can be fabricated and operated without the need for expensive infrastructure and skilled personnel, potentially solving real-world healthcare problems for both developed and developing countries. Using this technology, they also have developed a phone app that could detect bacteria and disease in the blood using images from a cellphone that could easily be analyzed from anywhere in the world. Please click on the top image to enlarge. 

Waseem Asghar, Ph.D., assistant professor of electrical engineering in the College of Engineering and Computer Science at FAU, co-first author on the study, along with Hadi Shafiee, Ph.D., instructor in medicine at the Division of Biomedical Engineering at Brigham and Women's Hospital, Harvard Medical School; Fatih Inci, Ph.D.; and Utkan Demirci, Ph.D., Stanford School of Medicine, senior authors on the study, have published their findings in Nature Scientific Reports in an article titled “Paper and Flexible Substrates as Materials for Biosensing Platforms to Detect Multiple Biotargets.” Other team members on the study include Mehmet Yuksekkaya, Ph.D.; Muntasir Jahangir; Michael H. Zhang; Naside Gozde Durmus, Ph.D.; Umut Atakan Gurkan, Ph.D., and Daniel R. Kuritzkes, M.D.

In the article, the researchers address the limitations of current paper and flexible material-based platforms and explain how they have integrated cellulose paper and flexible polyester films as new diagnostic tools to detect bioagents in whole blood, serum and peritoneal fluid. They employed three different paper and flexible material-based platforms incorporated with electrical and optical sensing modalities. They were able to demonstrate how these new materials can be widely applied to a variety of settings including medical diagnostic and biology laboratories.

Using paper and flexible substrates as materials for biosensors, Asghar and his colleagues have identified a new rapid and cost-effective way to diagnose diseases and monitor treatment in point-of-care settings. They have been able to show how their new platforms are uniquely able to isolate and detect multiple biotargets selectively, sensitively, and repeatedly from diverse biological mediums using antibodies.


Please click on the image to enlarge.

“There is a dire need for robust, portable, disposable and inexpensive biosensing platforms for clinical care, especially in developing countries with limited resources,” said Asghar.

Existing paper and flexible material-based platforms use colorimetric, fluorometric and electrochemical approaches that require complex labeling steps to amplify their signal, are very costly to fabricate and also require expensive equipment and infrastructure.

“The future of diagnostics and health monitoring will have potentially cell-phone based or portable readers sipping saliva or blood and continuously monitoring human health taking it way beyond where we are with counting steps today,” said Demirci, who is the corresponding author.

Asghar notes that because their materials are easy to make, easy to use, and can easily and safely be disposed by burning, they provide appealing strategies for developing affordable tools that have broad applications such as drug development, food safety, environmental monitoring, veterinary medicine and diagnosing infectious diseases in developing countries.

“Our paper microchip technologies can potentially have a significant impact on infectious diseases management in low- and middle-income countries where there is limited laboratory infrastructure,” said Shafiee.

Demirci notes that these platforms could potentially be adapted and tailored to detect other pathogens and biotargets with well-known biomarkers.

Source: Florida Atlantic University
Posted by RapidMicro at 10:42 AM
Labels: bacteria, biosensor, blood, disease, flexible, paper, pathogens, saliva, smartphone

No comments:

Post a Comment

Newer Post Older Post Home
Subscribe to: Post Comments (Atom)
  • Click to Show All Blog Posts

Search This Blog





Blog Archive

  • ►  2018 (5)
    • ►  December (1)
    • ►  October (1)
    • ►  July (1)
    • ►  April (1)
    • ►  February (1)
  • ►  2017 (4)
    • ►  October (1)
    • ►  September (1)
    • ►  August (1)
    • ►  April (1)
  • ►  2016 (7)
    • ►  December (1)
    • ►  August (1)
    • ►  May (5)
  • ▼  2015 (16)
    • ►  December (3)
    • ►  November (1)
    • ►  June (2)
    • ►  May (3)
    • ▼  April (1)
      • New Biosensing Platform Could Quickly and Accurate...
    • ►  March (1)
    • ►  February (3)
    • ►  January (2)
  • ►  2014 (42)
    • ►  December (3)
    • ►  November (3)
    • ►  October (6)
    • ►  September (4)
    • ►  July (3)
    • ►  June (4)
    • ►  May (2)
    • ►  April (4)
    • ►  March (3)
    • ►  February (3)
    • ►  January (7)
  • ►  2013 (71)
    • ►  December (2)
    • ►  November (4)
    • ►  October (3)
    • ►  September (8)
    • ►  August (4)
    • ►  July (7)
    • ►  June (12)
    • ►  May (6)
    • ►  April (5)
    • ►  March (3)
    • ►  February (10)
    • ►  January (7)
  • ►  2012 (56)
    • ►  December (6)
    • ►  November (3)
    • ►  October (5)
    • ►  September (2)
    • ►  August (4)
    • ►  July (3)
    • ►  June (7)
    • ►  May (4)
    • ►  April (7)
    • ►  March (2)
    • ►  February (5)
    • ►  January (8)
  • ►  2011 (64)
    • ►  December (7)
    • ►  November (1)
    • ►  October (7)
    • ►  September (3)
    • ►  August (5)
    • ►  July (4)
    • ►  June (13)
    • ►  May (3)
    • ►  April (6)
    • ►  March (10)
    • ►  February (3)
    • ►  January (2)
  • ►  2010 (55)
    • ►  December (6)
    • ►  November (7)
    • ►  October (16)
    • ►  September (7)
    • ►  August (5)
    • ►  July (8)
    • ►  June (4)
    • ►  May (2)

Popular Posts

  • Longitude Prize Bacterial Dx Competition Announces Seed Funding Winners
    On average antibiotics add 20 years to each person’s life. The development of antibiotics has been vital to our survival, yet the rise of ...
  • FDA Promotes Rapid Sterility Testing for Human Gene Therapy Products in its Draft Guidance for Investigational New Drug Applications (INDs)
    This week, FDA’s Center for Biologics Evaluation and Research (CBER) published six draft guidances relating to gene therapy, three of whic...
  • My Opinions on Sage Products Rapid Method Warning Letter (and a reply to Tim Sandle's Blog)
    Tim Sandle published a recent blog post concerning a (FDA) Warning Letter related to an inadequate validation of a rapid microbiological ...
  • USP 1116: Points to Consider and the Role of Rapid Methods
    At a recent PDA workshop on the revised USP Chapter 1116, Microbiological Evaluation of Clean Rooms and Other Controlled Environments, a n...
  • MIT Develops a Rapid, Paper-Based Zika Diagnostic Test
    A new paper-based test developed at MIT and other institutions can diagnose Zika virus infection within a few hours. The test, which disti...
  • CRISPR Used for Infectious Disease Diagnostics
    CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) are short, repeated DNA sequences found in the genomes of bacteria and o...
  • Comment on a Recent RMM Vendor Roundtable Discussion
    In the most recent European Pharmaceutical Review (2013, Vol. 18, Issue 4), two articles provided discussion on rapid microbiological met...
  • Colorado Researchers Fighting to Get Ahead of the Next Ebola Outbreak
    ReEBOV may be one of the most important technologies developed by Corgenix Medical Corp., but it's not a financial boon for the 25-yea...
  • Join Us in the Rapid Micro Methods LinkedIn Group!
    We have an active rapid microbiology discussion group on LinkedIn with more than 3,600 members! Many different industry sectors are repres...
  • Researchers Propose Rapid Ebola Test Using Nanotechnology
    Just as Ebola was finally fading from the headlines, it came back in the news with shocking reports: a Scottish nurse rehospitalized nine mo...

Follow by Email

Links

  • Microbiology Consultants, LLC
© Copyright 2010-2019 rapidmicromethods.com. All rights reserved. • Terms of Use • Advertise
LinkedIn  LinkedIn   Follow RapidMicro on Twitter  Twitter   Follow RapidMicro on Facebook  Facebook